Commentary: Transient Elastography and Fibrosis-4 Index as Predictors of Hepatocellular Carcinoma in Hepatitis C Virus Patients with Sustained Virological Response
1,2Paula G F da Silva, 3Flávia F Fernandes,1Cristiane A Villela-Nogueira
1Clementino Fraga Filho University Hospital, School of Medicine, Hepatology Division, Federal University of Rio de Janeiro, Brazil.
2Bonsucesso Federal Hospital, Department of Hepatology, Rio de Janeiro, Brazil.
3Pedro Ernesto University Hospital, Internal Medicine Department and Obesity Unit (SAI-Ob) Multiuse Clinical Research Center (CePeM), Rio de Janeiro, Brazil.
Global data from 2020 estimates that 57 million people have chronic hepatitis C virus (HCV) infection, accounting for 300,000 disease-related deaths and 1.5 million new infections annually1. In Brazil, from 2000 to 2024, 342,328 confirmed cases of infection were recorded, most of which were chronic2.
Follow-up of patients with HCV-related liver disease has advanced considerably over the past two decades3. Studies culminated in the development of direct-acting antiviral (DAA) therapy with high efficacy in achieving sustained virological response (SVR) for both acute and chronic infections1, 4. HCV eradication rates average 90-97%5.
DOI: 10.29245/2689-9981/2026/1.1190 View / Download Pdf